| cytokine storm syndrome | happen in | SARS-CoV-2 patients (count: 1) | |
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| Previous studies of COVID-19 patients have demonstrated that cytokine storm syndrome (CRS) could happen in SARS-CoV-2 infected patients [9, 10] .
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| SARS-CoV-2 infection | is | in moribund patients associated with cytokine storm 4 12 (count: 1) | |
| Importantly, in most moribund patients, SARS-CoV-2 infection is also associated with an inflammatory cytokine storm 4, 12 , which is mainly characterized by elevated plasma concentrations of interleukins 6 (IL-6).
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| dosage | attenuates | inflammation in patients with COVID-19 (count: 1) | |
| The effective dosage of antibody by timely administration attenuates the inflammation in patients with COVID-19, and facilitates the patients to get through acute exudation of pneumonia.
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| research | reveals cytokine storm in | COVID-19 patients (count: 1) | |
| Recent research reveals the fatal cytokine storm in critical COVID-19 patients.
-- Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China. medrxiv. 2020-03-16. | |
| 2019-nCoV | may cause cytokine storm in | 8 (count: 1) | |
| In a recent clinical report, 2019-nCoV may cause cytokine storm and multi-organ failure in severe pneumonia patients(8).
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| We | speculate in | lung inflammation caused by SARS-CoV-2 (count: 1) | |
| 19 We speculate in the lung inflammation caused by SARS-CoV-2 or the secondary systemic inflammation, the activated body stress system may lead to the increase of fibrinogen.
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| EAT density | inflammation in | COVID-19 patients (count: 1) | |
| This results suggested that lower EAT density showed the cardiac inflammation in COVID-19 patients.
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| COVID-19 pneumonia | process of is | inflammation reaction (count: 1) | |
| The pathological process of severe COVID-19 pneumonia is the inflammation reaction characterized by destruction of deep airway and alveolar [6] .
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| cytokines | indicating | relationship between inflammation in 2019-nCoV patients (count: 1) | |
| Our study demonstrated that pro-inflammatory cytokines IL-6, IL-17A were elevated in mostly patients, with significant higher level of IL-6, IL-17A and TNF-α in severe patients, indicating an underlying relationship between pulmonary inflammation and lung damage in 2019-nCoV patients.
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| COVID-19 attack | cause | alveolar damage in patients with baseline diseases (count: 1) | |
| Furthermore, COVID-19 has weak virulence, resulting in lighter imaging signs in these patients [7] ; 2) minors have immature lung structure development, resulting in atypical HRCT signs, and; 3) a COVID-19 attack on the immune system is more likely to cause diffuse alveolar damage and a large number of inflammatory exudations in middle-aged and older patients with more baseline diseases.
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| cytokine storm syndrome | subgroup of | patients with COVID-19 (count: 1) | |
| Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome.
-- COVID-19: consider cytokine storm syndromes and immunosuppression. The Lancet. 2020-03-16. | |
| hallmark | is | cytokine storm induced by COVID-19 (count: 1) | |
| Current available therapies -including non-specific anti-virals, antibiotics to treat secondary bacterial infections and sepsis, and corticosteroids to reduce inflammation -fail in severe disease where the hallmark is the cytokine storm induced by COVID-19 in the lung, visible as inflammatory lesions with ground-glass opacity on CT scan.
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| SARS-CoV-2 infection | leads to | downregulation (count: 1) | |
| SARS-CoV-2 infection leads to the downregulation of ACE2 expression, thus resulting in excessive production of angiotensin II by the related enzyme ACE.
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| cytokine storm onset | is in | COVID-19 (count: 1) | |
| Second, investigations are needed regarding the key pathways and immune cell types involved in cytokine storm onset in COVID-19; these will benefit the understanding of artificial-liver support system treatment for alleviating cytokine storm to reverse the disease process in patients with severe COVID-19 infection by rebalancing the immune system.
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