| SARS-CoV-2 acid | remaining over | 14 days after treatment (count: 1) | |
|---|---|
| Notably, 5 (23.8%) patients in the LPV/r group experienced adverse events including 3 with diarrhea, 2 loss of appetite and one abnormal liver function, especially one serious adverse event reporting a 79-year-old man with diabetes and hypertension experienced severe diarrhea and progressed to critical condition ECMO with SARS-CoV-2 nucleic acid remaining positive over 14 days after treatment.
-- reference not found! | |
| SARS-CoV-2 acid | conversion of were | After 14 days 76.2 % (count: 1) | |
| After 14 days of treatment, the positive-to-negative conversion of SARS-CoV-2 nucleic acid were 76.2% (16/21), 87.5% (14/16) and 71.4% (5/7) respectively in the LPV/r group, the arbidol group and the control group, without significantly statistical difference among groups (P =0.681) (table 2).
-- reference not found! | |
| COVID-19 | days of is | 5-10 days (count: 1) | |
| The incubation days of COVID-19 in Wuhan city is 5-10 days with a mean of 7 days (Fan et al.,
| |
| COVID-19 cases | developed symptoms on | 3.3 days earlier (count: 1) | |
| Our data also show that MTB infection is associated with more rapid development of symptoms ( Figure 1C-D) ; MTB coinfected COVID-19 cases developed symptoms on average 3.3 days earlier than their non-MTB-infected counterparts.
-- Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity. medrxiv. 2020-03-16. | |
| COVID-19 patients | were becoming for | antibodies from 7-12 days after onset (count: 1) | |
| COVID-19 patients were becoming reactive(positive) for specific antibodies from 7-12 days after the onset of morbidity.
| |
| SARS-CoV-2 infection | be ruled out | undetectable after 20 days of symptoms onset (count: 1) | |
| This finding indicates that SARS-CoV-2 infection can be ruled out if antibody against SARS-CoV-2 is still undetectable after 20 days of symptoms onset, or after 23 days from exposure (20 days plus a median incubation of 3-day [9] ).
-- reference not found! | |
| SARS-CoV-2 travellers | have | Over weeks have reported within days after their arrival (count: 1) | |
| Over the last few weeks, only a few SARS-CoV-2 infected travellers have been reported with symptoms within a few days after their arrival (15).
-- Interventions targeting air travellers early in the pandemic may delay local outbreaks of SARS-CoV-2. medrxiv. 2020-02-13. | |
| cells | were | Twenty-four hours after challenged with SARS-CoV-2 reporter plasmids (count: 1) | |
| On day 3, cells were switched to fresh medium with Puromycin at 2 ug/mL. Twenty-four hours after Puromycin selection, cells with transfected crRNAs were challenged with SARS-CoV-2 reporter plasmids or SARS-CoV-2 reporter lentivirus.
-- Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza. biorxiv. 2020-03-14. | |
| COVID-19 patients | developed kidney injury in | only 2 days after admission (count: 1) | |
| It is noteworthy that most COVID-19 patients developed acute kidney injury in the early period of hospitalization, especially in only 2 days after admission in patients with elevated baseline Scr.
-- Kidney impairment is associated with in-hospital death of COVID-19 patients. medrxiv. 2020-02-20. | |
| Median anti-SARS-CoV-2 IgG | is in | patients with severe illness within 35 days after symptom onset (count: 1) | |
| Median anti-SARS-CoV-2 IgG and IgM levels in patients with severe or nonsevere illness within 35 days after symptom onset. (
| |
| duration | was | 9.24 days for COVID-19 patients (count: 1) | |
| This duration was 9.24 (7.10-11.37) days for COVID-19 patients without pneumonia (n=17) and 10.45 (8.10-12.81) days for those with pneumonia (n=11).
| |
| COVID-19 incidence | could | Given incubation period of 4-6 days could reflective (count: 1) | |
| Given the median incubation period of 4-6 days for COVID-19 [11] , the overall COVID-19 incidence in provinces with lags of 2-3 weeks, or approximately 2-3 times the median incubation period, could be reflective of the second-or third-generation transmissions.
| |
| we | analyzed | lymphocyte subsets in blood of COVID-19 patients to at least 16 days later (count: 1) | |
| Next, we analyzed the kinetic changes of WBCs, neutrophils and monocytes as well as different lymphocyte subsets in the peripheral blood of COVID-19 patients from the disease onset to at least 16 days later.
| |
| we | Assuming | incubation period with mean of 5.2 days from study of COVID-19 cases (count: 1) | |
| Assuming an incubation period with a mean of 5.2 days from a separate study of early COVID-19 cases, 2 we inferred that infectiousness started from 2.5 days before symptom onset and reached its peak at 0.6 days before symptom onset (Figure 1b) .
-- reference not found! | |
| lockdown | are | effective in reduction with COVID-19 after about 11 days in china (count: 1) | |
| The daily statistics showed that lockdown are effective in reduction of incidence of confirmed cases with COVID-19 after about 11 days in china.
-- reference not found! | |
| Our study | demonstrated | transmission of COVID-19 in three days of incubation period (count: 1) | |
| Our study initially demonstrated asymptomatic transmission of COVID-19 in the incubation period, especially in the last three days of incubation period, by estimating the incubation period with the use of accurate exposure history of confirmed cases.
| |
| serial interval | was | 4.1 days for COVID-19 (count: 1) | |
| We observed the mean serial interval was 4.1 days for COVID-19, which is shorter than the 8.4-day and the 7.6-day mean serial interval reported for SARS and MERS, respectively.
| |
| COVID-19 cases | are | potential infection sources within three days prior (count: 1) | |
| In conclusion, the COVID-19 cases in the incubation period are potential infection sources, especially within three days prior to the symptom onset.
| |
| Eligibility criteria Adults | will | will recruited within 72 hours after confirmation of COVID-19 (count: 1) | |
| Eligibility criteria Adults in-hospital patients (>18 years old) will be recruited within 72 hours after confirmation of COVID-19 by real-time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) on oropharyngeal or nasopharyngeal swabs or stool samples.
| |
| 2019-nCoV strains | have | In days have separated (count: 1) | |
| Recently, a new type of pneumonia which is caused by 2019-nCoV has outbroken nationwide in China and the previous studies have shown that 2019-nCoV is like SARS-CoV. In the last few days, several 2019-nCoV strains have been successfully separated from patients and the results of sequencing data can be acquired on Sharing Avian Influenza Data and GenBank.
-- Predictions for the binding domain and potential new drug targets of 2019-nCoV. biorxiv. 2020-03-02. | |
| We | plot | effect of severity of COVID-19 by exercise hours in Figure 2 (count: 1) | |
| We plot the effect of the severity of COVID-19 in the location on life satisfaction by the exercise hours of individuals in Figure 2 .
-- Health, distress, and life satisfaction of people one-month into COVID-19 outbreak in China. medrxiv. 2020-03-16. | |
| SARS-CoV-2 RNA | was | detected in stool 8-20 days after (count: 1) | |
| Notably, SARS-CoV-2 RNA was detected in the stool of these children 8-20 days after negative conversion of viral RNA in respiratory specimens.
-- Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase. medrxiv. 2020-03-13. | |
| R0 | using incidence during | 23 days of COVID-19 Algeria (count: 1) | |
| In order to predict the cumulative incidence (cases number) of COVID-19 Algerian epidemic in the coming weeks we used the mathematical model (Alg-COVID-19) defined as: The approach implemented to estimate the basic reproduction numbers (R0) in this model is to calculate the average R0 using the real chronological incidence (case number) during the first 23 days of the COVID-19 Algeria epidemic between February 25 and March 19, 2020, so that, we used the equation (3) derived from the equation (1).
-- reference not found! | |
| future COVID-19 | confirmed cases with | weather observations in sequence of 15 days for seven (count: 1) | |
| We used this best fitted model to predict future COVID-19 daily confirmed new cases with weather observations and forecasts in a sequence of 15 days for seven .
-- reference not found! | |
| SARS-CoV-2 supernatants | were | 48 hours later mixed (count: 1) | |
| 48 hours later, SARS-CoV-2 pseudovirus-containing supernatants were mixed with at least 6 serially diluted the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
-- reference not found! | |
| data | indicate | replication of SARS-CoV-2 during 5 days after symptoms onset (count: 1) | |
| Together, these data indicate active replication of SARS-CoV-2 in the throat during the first 5 days after symptoms onset.
| |
| COVID-19 surveillance | has in | has place since 10 January 2020 3 days after (count: 1) | |
| Specific COVID-19 surveillance has been in place in France since 10 January 2020, 3 days after the identification of the SARS-CoV-2 in China.
-- reference not found! | |
| interest | was | 10-14 days earlier than incidence peak of COVID-19 (count: 1) | |
| We also found that the peak interest for these keywords in Internet search engines and social media data was 10-14 days earlier than the incidence peak of COVID-19 published by the NHC.
-- reference not found! | |
| we | have | wait for at least 14 days after anti-COVID-19 epidemic (count: 1) | |
| In other words, we have to wait for at least 14 days after the massive anti-COVID-19 epidemic without using information derived from F ′ ′ (x).
-- First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model. Global Health Research and Policy. 2020. | |
| COVID-19 epidemic | was responsive Despite | delay of 43 days from cases (count: 1) | |
| Despite a delay of 43 days from the first confirmed cases on December 8, 2019 to January 20, 2020, the COVID-19 epidemic was highly responsive to massive interventions, supporting the effectiveness of these interventions.
-- First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model. Global Health Research and Policy. 2020. | |
| it | be | 3-6 days for 2019-nCoV (count: 1) | |
| Overall, infection caused by the 2019-nCoV shares many clinical similarities with infection caused by SARS-CoV. A typical human coronavirus has an incubation period of 2-4 days; it is estimated to be 3-6 days for the 2019-nCoV, and 4-6 days for SARS-CoV. 15, 16, 29, 30 Infection with 2019-nCoV, similar to SARS-CoV, presents with non-specific symptoms such as malaise, fever, and dry cough at the prodromal phase.
-- The Novel Coronavirus: A Bird's Eye View. Int J Occup Environ Med. 2020. | |
| SARS-CoV-2 | is detected within | 1-2 days after patient symptoms (count: 1) | |
| Subsequent detailed clinical investigations demonstrated that SARS-CoV-2 is detected within 1-2 days after patient symptoms, peaking 4-6 days later and clearing within 18 days [4] .
-- SARS Coronavirus Redux. Trends in Immunology. 2020-03-12. | |
| SARS-CoV-2 | was | found days ago (count: 1) | |
| Since SARS-CoV-2 was found a few days ago to utilise the same cell surface receptor ACE2 (expressed in lung, heart, kidney and intestine) as SARS-CoV-1 [85, 86] (Table 1) , it may be hypothesised that chloroquine also interferes with ACE2 receptor glycosylation thus preventing SARS-CoV-2 binding to target cells.
-- New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?. International Journal of Antimicrobial Agents. 2020-03-12. | |
| SARS-CoV-2 RNA | could | could detected for 20 days in third (count: 1) | |
| SARS-CoV-2 RNA could be detected for 20 days or longer in a third of patients who survived in our cohort, and one patient had SARS-CoV-2 RNA detected for 25 days.
-- reference not found! | |
| COVID-19 particles | survive | days on surfaces (count: 1) | |
| 4 Emerging research also suggests that COVID-19 viral particles remain viable in aerosol for several hours and can survive several days on multiple surfaces.
-- reference not found! | |
| SARS-CoV-2 | has | From days has topic (count: 1) | |
| From the first days of 2020, SARS-CoV-2 has been the main topic discussed all over the world.
-- reference not found! | |
| SARS-CoV-2 acid test results | were negative After | 8 days of treatment (count: 1) | |
| After 8 days of treatment, the SARS-CoV-2 nucleic acid test results were negative in throat swab samples twice, cough had improved, and laboratory tests results and computed tomographic chest images had improved (Fig 1) .
-- reference not found! | |
| SARS-CoV-2 | survive for | hours on environments (count: 1) | |
| This latter route is due to the fact that the SARS-CoV-2 (as other coronaviruses) can survive for several hours on inanimate environments (e.g. objects surfaces) [14] .
-- reference not found! | |
| SARS-CoV-2 | pneumonia for | two days before admission (count: 1) | |
| Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2, Journal of Infection, https://doi.org/10.1016/j.jinf.2020.Common novel coronavirus pneumonia in a 37-year-old man with fever for six days and cough for two days before admission.
-- Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. Journal of Infection. 2020-02-25. | |
| SARS-CoV-2 RNA | persisted for | median of 20 days in survivors (count: 1) | |
| In the current study, we found that the detectable SARS-CoV-2 RNA persisted for a median of 20 days in survivors and that it was sustained until death in nonsurvivors.
| |
| time | was | only 9 days among patients with COVID-19 infection (count: 1) | |
| Most patients had some degree of dyspnoea at presentation, because the time from onset of symptoms to the development of acute respiratory distress syndrome (ARDS) was only 9 days among the initial patients with COVID-19 infection [1] .
-- reference not found! | |
| finding | reflected | increased until three days before increased of COVID-19 cases (count: 1) | |
| This finding reflected the increased of googling activities in one until three days before the increased of COVID-19 cases.
-- Applications of google search trends for risk communication in infectious disease management: A case study of COVID-19 outbreak in Taiwan. International Journal of Infectious Diseases. 2020-03-12. | |
| name 2019-nCoV | hours before | release (count: 1) | |
| The WHO decided to prefer the name "2019-nCoV" hours before release of the previous report by the present author in January 2020 [2] , although the final decision on the virus' official name still awaited the International Committee on Taxonomy of Viruses.
-- Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus. Computers in Biology and Medicine. 2020-02-26. | |
| patient 's family members | have | have diagnosed with 2019-nCoV infection within 14 days before onset (count: 1) | |
| being at high risk of 2019-nCoV infection because the patient's family members or caregivers have been diagnosed with 2019-nCoV infection, had close contact with someone with probable or confirmed 2019-nCoV, had close contact with someone with pneumonia of unknown cause, are living in or travelling to epidemic areas, or have been in animal markets or close contact with wild animals, within 14 days before the onset of illness.
-- A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units. The Lancet Child & Adolescent Health. 2020-04-30. | |
| period | appeared | short at approximately 48 hours consistent with reports of incubation period of SARS-CoV-2 6 (count: 1) | |
| Based on this assumption, the period from exposure to disease onset appeared short, at approximately 48 hours, consistent with recent reports of the incubation period of SARS-CoV-2 6 .
-- Novel coronavirus disease (Covid-19): The first two patients in the UK with person to person transmission. Journal of Infection. 2020-02-28. | |
| she | was | With three 41 results of RT-PCR tests for SARS-CoV-2 discharged after 24 days of hospitalization (count: 1) | |
| With three 41 consecutive negative results of real-time RT-PCR tests for SARS-CoV-2 in 42 nasopharyngeal swab, she was discharged after 24 days of hospitalization.
-- A case of COVID-19 and pneumonia returning from Macau in Taiwan: Clinical course and anti-SARS-CoV-2 IgG dynamic. Journal of Microbiology, Immunology and Infection. 2020-03-10. | |
| SARS-CoV-2 | detected in | their swabs 44 sampled after 14 days ' quarantine (count: 1) | |
| None of 43 four members in the family had SARS-CoV-2 detected in their nasopharyngeal swabs 44 sampled after 14 days' quarantine.
-- A case of COVID-19 and pneumonia returning from Macau in Taiwan: Clinical course and anti-SARS-CoV-2 IgG dynamic. Journal of Microbiology, Immunology and Infection. 2020-03-10. | |
| work | provides | evidence for incubation period for COVID-19 of approximately 5 days similar (count: 1) | |
| This work provides additional evidence for a median incubation period for COVID-19 of approximately 5 days, similar to SARS.
-- reference not found! | |
| He | was | discharged after 8 days following two nose negative for SARS-CoV-2 (count: 1) | |
| He was discharged after 8 days, following two sequential nose and throat swabs negative for SARS-CoV-2 by PCR.
-- reference not found! | |